Clean from cleanroom to outfall.

We prepare the HVAC energy, hazardous waste and effluent data PROPER, regulators and buyer auditors ask for at every phase of your plant, and bring it together on Ailesh+.

See your phase Talk to us about your plant

One data set for PROPER, regulators and buyers.

AHU sub-meters, the hazardous-waste balance and effluent test results are reused by every obligation. Set up from the design stage, that data cuts energy cost and makes audits easier.

Risk

WHO guidance makes antibiotic residues in effluent a reference for regulators and medicine buyers, yet national standards set no limit per substance. At home, PROPER participants under an administrative sanction are rated Red automatically.

0.05 µg/L default target concentration for antibiotics in plant effluent.

According to the AMR Industry Alliance, 2022

Opportunity

Cleanroom HVAC is the largest energy user in a pharma plant. Turning air supply down outside production hours can cut the bill, provided each change is validated under GMP.

±65% of a pharmaceutical facility's energy goes to HVAC.

According to LBNL/ENERGY STAR, 2008

Priority

Sub-meter every AHU and chiller, set an effluent residue baseline per line, and tidy up the hazardous-waste balance. That data fills PROPER, energy management reports and buyer audits at once.

PROPER (Environment Ministry Regulation 7/2025)
annual cycle
A Green rating requires an environmental management system, LCA, and energy and water efficiency.
According to the BPK legal database; KLH/BPLH, 2025
Energy management (Government Regulation 33/2023 and Energy Ministry Regulation 8/2025)
ministry regulation in force since 13 Mar 2025
Plants using 4,000 TOE a year or more must run an energy management system, appoint an energy manager and report to the energy ministry.
According to the BPK legal database; pasal.id
Hazardous waste (Government Regulation 22/2021 and Environment and Forestry Ministry Regulation 6/2021)
in force since 1 Apr 2021
Hazardous waste generated at 50 kg a day or more may be stored for at most 90 days before it goes to a licensed party.
According to the BPK legal database; pasal.id

Your HVAC bill is set when the zoning is drawn.

Cleanliness grades, air changes and the effluent plant design lock in energy cost and effluent risk for the life of the plant. Pick your phase to see what needs to be ready.

Phase 1: Raw water and receiving river are chosen with the site.

A pharma plant depends on stable raw water, power that must never fail and a river that receives its effluent. Figures recorded before the plant exists become the reference for PROPER and buyer audits.

What needs to be ready

- 1.1
  1.1 Raw water for purified water
  Map the source, quality and water-use licence before the RO and distillation systems are designed.
  According to Government Regulation 30/2024 and Public Works Ministry Regulation 2/2024
  - Water audit
  - Waste+
- 1.2
  1.2 Receiving-river baseline
  Measure active-ingredient residues upstream and downstream of the planned outfall so the plant's contribution can be isolated later.
  According to WHO, 2024
  - Water audit
  - IoT
- 1.3
  1.3 Environmental document screening
  Secure the spatial approval (KKPR) and the document type set by Amdalnet screening, since API plants using large volumes of solvent usually need a full environmental impact assessment (AMDAL).
  According to Government Regulation 28/2025
  - Environmental permits
  - PROPER+

Phase 2: GMP zoning and the energy bill are drawn together.

Cleanliness grades, air change rates and pressure differentials set the HVAC load for the life of the plant. The environmental documents, technical approvals and effluent plant design are processed in this same phase.

What needs to be ready

- 2.1
  2.1 Efficient HVAC from the first drawing
  Design variable air volume, out-of-hours setbacks and heat recovery together with the cleanroom zoning.
  HVAC energy fell 30–50% after a switch to variable air volume at one research facility
  According to LBNL/ENERGY STAR, 2008
  - Energy efficiency
  - Energy+
- 2.2
  2.2 An effluent plant with an advanced stage
  Biological treatment alone does not hold back enough antibiotic residue, so plan ozone, activated carbon or membranes at the design stage.
  - Water audit
  - PROPER+
- 2.3
  2.3 A hazardous-waste store by waste type
  Design separate storage for expired products, laboratory solvents and cytotoxic waste, and put the specification into the Environmental Approval.
  According to Environment and Forestry Ministry Regulation 6/2021
  - Environmental permits
  - Waste+

Phase 3: Meters go in while the ducts are still open.

Sub-meters on each AHU, chiller and purified-water system are cheapest to fit during installation. The IQ, OQ and PQ qualification already under way can record each room's energy baseline at the same time.

What needs to be ready

- 3.1
  3.1 Sub-meters per utility
  Fit electricity meters on every AHU, chiller, compressor and purified-water system before the ceilings close.
  energy monitoring and control saves around 5% or more
  According to LBNL/ENERGY STAR, 2008
  - Energy audit
  - IoT
- 3.2
  3.2 Baseline during qualification
  While air change rates and pressure differentials are tested, log the AHU's power use too as a later reference.
  - Energy audit
  - Energy+
- 3.3
  3.3 Effluent plant trial
  Run the plant on a load that mimics active-ingredient residues before the first batch, within the trial period set by the technical approval.
  According to Environment and Forestry Ministry Regulation 5/2021
  - Water audit
  - IoT

Phase 4: The first year becomes the reference for every report.

Energy intensity per batch, effluent residues and base-year emissions are set here. Meters recording from the first batch make those figures auditable by regulators and buyers.

What needs to be ready

- 4.1
  4.1 Operating certificates for effluent and emissions
  Apply for the operating certificate (SLO) after trial runs of the effluent plant and boiler, since discharging without one is prohibited once the trial period ends.
  According to Environment and Forestry Ministry Regulation 5/2021
  - Environmental permits
  - PROPER+
- 4.2
  4.2 Energy and greenhouse gas baseline
  Set energy indicators per AHU and chiller, then calculate Scope 1 from boilers, generators and refrigerant and Scope 3 from imported APIs.
  According to Energy Ministry Regulation 8/2025 and Presidential Regulation 110/2025
  - GHG accounting
  - Carbon+
- 4.3
  4.3 Entering PROPER and buyer audits
  Prepare your first environmental monitoring report (RKL-RPL), the hazardous-waste balance and evidence for Pharmaceutical Supply Chain Initiative (PSCI) audits by multinational buyers.
  - PROPER
  - PROPER+

Phase 5: Evidence of efficiency separates Green from Blue.

PROPER Green and Gold assess evidence of energy, water and waste efficiency, while the same figures cut HVAC cost. Investors and buyers read that data in tenders and in PSPK reports, Indonesia's version of IFRS S1 and S2.

2 of 39 PROPER Gold winners in 2024–2025 came from the pharmaceutical industry.

According to KLH/BPLH via Katadata, 2026

What needs to be ready

- 5.1
  5.1 HVAC recommissioning
  Check setbacks, air change rates and duct leakage, then carry out energy audit recommendations on schedule.
  a 1.1-year payback at one facility
  According to LBNL/ENERGY STAR, 2008
  - Energy audit
  - Energy+
- 5.2
  5.2 Hazardous waste and expired stock
  Reduce it through FEFO rotation and solvent recovery, then send the rest to a licensed treater under an electronic manifest.
  According to Environment and Forestry Ministry Regulation 6/2021
  - Waste-to-X
  - Waste+
- 5.3
  5.3 Antibiotic residues and the EU market
  Keep residues below PNEC-based targets, and estimate your cost exposure under the EU Urban Wastewater Treatment Directive if you supply medicines to Europe.
  According to WHO, 2024; Directive (EU) 2024/3019
  - Market compliance
  - ESG+

Phase 6: A new line reopens the old permit.

An extra sterile line, an API plant or an HVAC retrofit changes capacity, feedstock and waste loads. A retired line also leaves expired stock and solvent tanks that must be handled as hazardous waste.

What needs to be ready

- 6.1
  6.1 Permit amendments before a new line
  File the amendment before new capacity, a new production technique or new feedstock comes into use, since changes not reflected in your permits can now draw a fine.
  According to Government Regulation 22/2021 and Environment Ministry Regulation 6/2026
  - Environmental permits
  - PROPER+
- 6.2
  6.2 A domestic API plant
  Compare the carbon footprint of local and imported APIs, then prepare the AMDAL and emission approval for solvents and VOCs.
  - LCA & product footprint
  - Carbon+
- 6.3
  6.3 Retiring a line
  Destroy expired stock through a licensed treater, clean the solvent tanks and remediate contaminated land until it is declared complete.
  According to Environment and Forestry Ministry Regulation P.101/2018
  - Waste-to-X
  - Waste+

From the API store to the refrigerated truck.

Every unit carries its own obligations and its own data. Open them one by one.

Raw material and cold stores

APIs, excipients, solvents and packaging materials arrive here, and most APIs come from abroad.

Emissions
Waste
Energy
Safety

What you can manage

FEFO rotation so materials do not expire
Log cold-room refrigerant top-ups
Ask API suppliers for emissions per kilogram

90% of the pharmaceutical industry's raw materials are still imported

Source: Ministry of Industry via CNBC Indonesia, 2026

GHG accounting
Carbon+

Solid and sterile production

Materials are weighed, granulated, dried and pressed into tablets, while sterile products are filled aseptically in Grade A and B rooms.

Energy
Water
Waste
Safety

What you can manage

Log dryer and machine power per batch
Handle used HEPA filters as hazardous waste
Validate cleaning that saves water and detergent

±15% of facility energy goes to formulation and packaging

Source: LBNL/ENERGY STAR, 2008

Energy audit
Energy+

HVAC and utilities

AHUs hold cleanroom air changes and pressure, while RO, distillation, boilers and chillers supply purified water, steam and cooling.

Energy
Emissions
Water

What you can manage

HVAC setbacks outside production hours
Reuse RO reject for non-contact duties
Detect chiller refrigerant leaks early

±65% of pharmaceutical facility energy goes to HVAC

Source: LBNL/ENERGY STAR, 2008

Energy efficiency
Energy+

Packaging

Products are packed into PVC-aluminium blisters, bottles and cartons, and packaging rejects and foil offcuts leave the line.

Waste
Energy

What you can manage

Log packaging tonnage by type
Keep packaging rejects apart from hazardous waste
Assess alternatives to hard-to-recycle blisters

LCA & product footprint
Waste+

QC laboratory

HPLC, GC, microbiology and stability testing generate spent solvents, reagents, contaminated media and expired samples.

Waste
Energy
Safety

What you can manage

Segregate lab hazardous waste by type
Autoclave microbiology media before disposal
Switch fume hoods to variable air volume

Up to 70% energy saving from variable-volume fume hoods at one research facility

Source: LBNL/ENERGY STAR, 2008

Environmental permits
Waste+

Effluent plant and waste store

Effluent is equalised, treated biologically and polished with ozone or activated carbon, while the hazardous-waste store ships to licensed treaters.

Water
Waste
Community

What you can manage

Sample antibiotic residues per line regularly
Report the hazardous-waste balance every six months
Characterise treatment sludge before classifying it

0.05 µg/L default antibiotic target in effluent

Source: AMR Industry Alliance, 2022

Finished goods and distribution

Finished goods ship at 2–8 °C or room temperature to distributors and health facilities, and returns and expired stock come back in.

Energy
Emissions
Waste

What you can manage

Keep temperature data for every shipment
Calculate fleet and haulier emissions per tonne-km
Return expired stock as manifested hazardous waste

GHG accounting
Carbon+

R&D and formulation

New formulations, solvent choices and domestic API development set a product's carbon footprint and hazardous waste for years.

Emissions
Waste
Energy

What you can manage

Compare the LCA of each formulation and supplier option
Choose low-hazard solvents from lab scale
Meter fume hoods and stability chambers

±30% of pharmaceutical facility energy is used in R&D areas

Source: LBNL/ENERGY STAR, 2008

LCA & product footprint
Carbon+

Residents and workforce

Permanent and contract staff work in production, warehousing and cleaning, while nearby residents live with odour, traffic and solvent risk.

Community
Safety

What you can manage

Monitor active-ingredient exposure and worker health
Log and answer every resident complaint
Measure community health programmes with SROI

319,382 workplace accidents recorded nationally in 2025

Source: Manpower Ministry via GoodStats, 2026

Social impact
Social+

1 / 9

Typical facility illustration; not a specific site.

From AHU sub-meters to the PSPK report.

Without a single source, engineering, HSE and sustainability teams compile energy, waste and effluent figures in a different spreadsheet every year. Ailesh+ brings them together: IoT sub-meters feed Energy+, refrigerant and API supplier data go into Carbon+, and hazardous waste and water sit in Waste+. PROPER+ and ESG+ then build your PROPER and PSPK reports from that same source.

Meet Ailesh+Try the demo

Which phase is your plant in?

Tell us the phase, from choosing a site to preparing a new line. We'll map the meters, documents and data that need to be ready.

Email us at [email protected]Check your plant's PROPER readiness, free

Clean from cleanroom to outfall.

One data set for PROPER, regulators and buyers.

Risk

Opportunity

Priority

PROPER (Environment Ministry Regulation 7/2025)

Energy management (Government Regulation 33/2023 and Energy Ministry Regulation 8/2025)

Hazardous waste (Government Regulation 22/2021 and Environment and Forestry Ministry Regulation 6/2021)

Your HVAC bill is set when the zoning is drawn.

Phase 1: Raw water and receiving river are chosen with the site.

What needs to be ready

1.1 Raw water for purified water

1.2 Receiving-river baseline

1.3 Environmental document screening

Phase 2: GMP zoning and the energy bill are drawn together.

What needs to be ready

2.1 Efficient HVAC from the first drawing

2.2 An effluent plant with an advanced stage

2.3 A hazardous-waste store by waste type

Phase 3: Meters go in while the ducts are still open.

What needs to be ready

3.1 Sub-meters per utility

3.2 Baseline during qualification

3.3 Effluent plant trial

Phase 4: The first year becomes the reference for every report.

What needs to be ready

4.1 Operating certificates for effluent and emissions

4.2 Energy and greenhouse gas baseline

4.3 Entering PROPER and buyer audits

Phase 5: Evidence of efficiency separates Green from Blue.

What needs to be ready

5.1 HVAC recommissioning

5.2 Hazardous waste and expired stock

5.3 Antibiotic residues and the EU market

Phase 6: A new line reopens the old permit.

What needs to be ready

6.1 Permit amendments before a new line

6.2 A domestic API plant

6.3 Retiring a line

From the API store to the refrigerated truck.

Raw material and cold stores

Solid and sterile production

HVAC and utilities

Packaging

QC laboratory

Effluent plant and waste store

Finished goods and distribution

R&D and formulation

Residents and workforce

From AHU sub-meters to the PSPK report.

Which phase is your plant in?